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Thursday, August 6, 2020 | History

1 edition of Bioassay of proflavine for possible carcinogenicity found in the catalog.

Bioassay of proflavine for possible carcinogenicity

by United States. National Cancer Institute. Carcinogen Bioassay and Program Resources Branch

  • 157 Want to read
  • 5 Currently reading

Published by Carcinogen Bioassay and Program Resources Branch, Carcinogenesis Program, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of Health in Bethesda, Md .
Written in English

    Subjects:
  • Carcinogens,
  • Safety measures,
  • Toxicology,
  • Synthetic products,
  • Carcinogenesis,
  • Dyes and dyeing

  • Edition Notes

    Other titlesProflavine.
    SeriesDHEW publication ; no. (NIH) 77-805, National Cancer Institute carcinogenesis technical report series -- no. 5., NIH publication -- no. 77-805.
    The Physical Object
    Paginationviii, 103 p. ;
    Number of Pages103
    ID Numbers
    Open LibraryOL25916020M

      This book presents a range of "bench top" bioassay techniques useful for natural product and pharmaceutical chemists involved in drug discovery and pharmacognosy. The contents detail a number of enzyme-based assays, cell-based functional bioassays and receptor radioligand binding assays along with detailed descriptions of each by: A bioassay involves use of a biological organism to test for chemical toxicity. Perhaps the oldest and most commonly known example is the canary in the coal mine. Traditionally, coal miners have taken caged canaries down into the mines to help ensure a safe air supply.

    Bioassays Bioassays are experiments that use living things to test the toxicity of chemicals. Students can use bioassays to conduct a wide range of experiments relating to toxicity of known chemical solutions or unknown mixtures such as samples of water, sediment, or soil from the environment. • Replication –repetition of the bioassay at a different time but under the same conditions (as much as possible) • Subsets within a replication = pseudo-replication Properties of a Good Bioassay 1) Reproducibility (the “litmus test” of science) 2) Results easily File Size: KB.

    The results of this carcinogenicity bioassay not only confirm, but also reinforce the first experimental demonstration of aspartame's multipotential carcinogenicity at a dose level close to the acceptable daily intake ADI for humans. Archive IARC Evaluation of the Carcinogenicity of Pesticides: Epidemiological Evidence. Dana Loomis, PhDFile Size: KB.


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Bioassay of proflavine for possible carcinogenicity by United States. National Cancer Institute. Carcinogen Bioassay and Program Resources Branch Download PDF EPUB FB2

Carcinogenesis Program (National Cancer Institute (U.S.)). Carcinogen Bioassay and Program Resources Branch. Bioassay of proflavine for possible carcinogenicity (OCoLC) Material Type: Government publication, National government publication: Document Type: Book: All Authors / Contributors: Carcinogenesis Program (National Cancer.

Get this from a library. Bioassay of proflavine for possible carcinogenicity. [Carcinogenesis Program (National Cancer Institute (U.S.)). Carcinogen Bioassay and Program Resources Branch.]. A bioassay of the carcinogenicity of proflavine monohydrochloride hemihydrate was conducted using Fischer /CR rats and B6C3F1 mice.

The compound was administered in the diet at concentrations of and ppm to groups of 50 rats for weeks and at concentrations of and ppm to groups of 50 mice for weeks. BIOASSAY OF PROFLAVINE FOR POSSIBLE CARCINOGENICITY. Carcinogen Bioassay and Program Resources Branch Carcinogenesis Program Division of Cancer Cause and Prevention National Cancer Institute National Institutes of Health Bethesda, Maryland DHEW Publication No.

(NIH)   BIOASSAY OF STYRENE FOR POSSIBLE CARCINOGENICITY. CAS No. NCI-CG-TR U.S. DEPARTMENT OF HEALTH, EDUCATION AN,D WELFARE Public Health Servic e National Institute of Healts h. C~O g. A bioassay of beta-2'-deoxythioguanosine monohydrate (b-TGdR) for possible carcinogenicity was conducted by administering the test chemical by intraperitoneal injection to Sprague-Dawley rats and B6C3F1 mice.

Groups of 35 rats of each sex were administered b-TGdR in a buffered saline and polysorbate 80 vehicle at one of two doses, either Bioassay of trisodium ethylenediaminetetraacetate trihydrate for possible carcinogenicity Published: () Bioassay of parathion for possible carcinogenicity Published: ().

Long-term animal bioassays for carcinogenicity are used regularly to determine whether chemical agents are capable of inducing cancer in exposed animals. Two important aspects of current bioassays are that testing covers a substantial portion of the lifespan of the test species and that high doses.

A bioassay is an analytical method to determine concentration or potency of a substance by its effect on living cells or tissues. Bioassays are quantitative biological assays used to estimate the potency of agents by observing their effects on living animals (in vivo) or tissue/cell culture systems (in vitro).

A bioassay experiment can either be qualitative or quantitative, direct or indirect. The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume.

The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays.

A bioassay of phenol to test for possible carcinogenicity was conducted by providing this substance in drinking water to F rats and B6C3F1 mice. Groups of 50 rats and 50 mice of each sex were given drinking water containing 2, or 5, ppm phenol for weeks.

As matched controls, groups of 50 rats and 50 mice of each sex received tap water. Bioassay definition is - determination of the relative strength of a substance (such as a drug) by comparing its effect on a test organism with that of a standard preparation.

carcinogenicity studies are caused by a non-genotoxic mechanism for which rodents are particularly sensitive, i.e.: continuous release of calcitonin due to persistent File Size: KB. Both are procedures by which the potency or the nature of a substance is estimated by studying its effects on living matter.

Bioassay is a procedure for the determination of the concentration of a particular constitution of a mixture [].

Structure of Biological Assay. The typical bioassay involves a stimulus applied to a subject. about potential carcinogenicity; the third pro-vides direct evidence of carcinogenicity in animals; the fourth produces direct evidence about cancer in man. These categories are brief-ly described in table Probably no statement made in the last col-umn of table 23 is free from dispute.

Results may be, and frequently are, challenged for sev. bioassay (bī′ō-ăs′ā′, -ă-sā′) n. Determination of the strength or biological activity of a substance, such as a drug, by comparing its effects with those of a standard preparation on a test organism.

A test used to determine such strength or activity. tr.v. bioassayed, bioassaying, bioassays To cause to. bioassay: [ bi″o-as´a ] determination of the active power of a drug sample by comparing its effects on a live animal or an isolated organ preparation with those of a reference standard.

Animal Carcinogenicity Studies: 3. Alternatives to the Bioassay. carcinogenicity bioassay in the general literature and the potential for the possible incorporation of alternative tests. Bioassays synonyms, Bioassays pronunciation, Bioassays translation, English dictionary definition of Bioassays.

bioassay - appraisal of the biological activity of a substance by testing its effect on an organism and comparing the result with some agreed standard. Daphnia laevis is a cladoceran with a wide distribution in the Americas.

REGULATORY TOXICOLOGY AND PHARMACOLOGY 3, () The Power and Interpretation of the Carcinogenicity Bioassay D. CLAYSON,I D. KREWSKI, AND 1. MUNRO Health Protection Branch, Health and Welfare Canada, Ottawa, Canada Received Carcinogenicity is a major consideration in the assessment of risks due to environmental Cited by:.

Animal Carcinogenicity Studies: 3. Alternatives to the Bioassay Andrew Knight,1 Jarrod Bailey2 and Jonathan Balcombe3 1Animal Consultants International, London, UK; 2School of Population and Health Sciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK; 3Physicians Committee for.As in the case of the mouse bioassay, interpreting these bioassay results for estimating low-dose human cancer is highly problematic.

4. Challenges interpreting and utilizing the NTP bioassays. In the past four decades many hundreds of chemical agents have been tested for carcinogenicity through standardized bioassays (NRC, ; p. 17).

A Cited by: standards, which covers genotoxicity, carcinogenicity, and reproductive toxicity, describes carcinogenicity testing as the means "to determine the tumorigenic potential of devices, materials, and/or extracts to.